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A prospective cohort study involving 100000 subjects found that the risk of breast cancer increased by 25% (HR=1.25, 95% CI 1.06-1.47) and the risk of prostate cancer increased by 31% (HR=1.31, 95% CI 1.09-1.57) in the highest quintile of IGF-1

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Histologic differentiation from melanoma may usually be made based on the overall symmetry of the lesion and the apparent cytologic maturation of nevus cells at the base of the lesion